Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes
نویسندگان
چکیده
منابع مشابه
Stem cell factor SALL4, a potential prognostic marker for myelodysplastic syndromes
BACKGROUND Myelodysplastic syndromes (MDS) are a group of heterogeneous diseases with variable clinical course. Predicting disease progression is difficult due to lack of specific molecular marker(s). SALL4 plays important roles in normal hematopoiesis and leukemogenesis. SALL4 transgenic mice develop MDS prior to acute myeloid leukemia (AML) transformation. However, the role of SALL4 in human ...
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UNLABELLED BACKGROUND Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myel...
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Gerard Socie, MD, PhD, is Head of the HematologyImmunology-Oncology Division at the Hospital St Louis, Paris; Professor of Hematology at the University Paris 7; and current President of the French Society of Hematology Financial and other disclosures provided by the author using the ICMJE (www.icmje.org) Uniform Format for Disclosure of Competing Interests are available with the full text of th...
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Myelodysplastic syndromes (MDS) are a group of disorders characterized by variable cytopenias and ineffective hematopoiesis. Hematopoietic stem cells (HSCs) and myeloid progenitors in MDS have not been extensively characterized. We transplanted purified human HSCs from MDS samples into immunodeficient mice and show that HSCs are the disease-initiating cells in MDS. We identify a recurrent loss ...
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ژورنال
عنوان ژورنال: Journal of Hematology & Oncology
سال: 2013
ISSN: 1756-8722
DOI: 10.1186/1756-8722-6-73